Rs2671655 single nucleotide polymorphism modulates the risk for gastric cancer in Helicobacter pylori-infected individuals: a genome-wide association study in the Korean population.

ABSTRACT:

Objective

To identify genetic variations which is associated with gastric cancer (GC) risk according to Helicobacter pylori infection.

Methods

This study incorporated 527 GC patients and 441 controls from a cohort at Seoul National University Bundang Hospital. The associations between GC risk and single nucleotide polymorphisms were calculated, stratified by H. pylori status, adjusting for age, sex, and smoking. mRNA expression from non-cancerous gastric mucosae was evaluated using reverse transcription quantitative polymerase chain reaction.

Results

In the entire cohort, genome-wide association study showed no significant variants reached the genome-wide significance level. In the H. pylori-positive group, rs2671655 (chr17:47,468,020;hg19, GH17J049387 enhancer region

SUBMITTER: Shin CM 

PROVIDER: S-EPMC8943788 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature