No increase in inflammation in late-life major depression screened to exclude physical illness.

ABSTRACT: Depression is a common and debilitating disorder in the elderly. Late-life depression (LLD) has been associated with inflammation and elevated levels of proinflammatory cytokines including interleukin (IL)-1β, tumor necrosis factor-alpha, and IL-6, but often depressed individuals have comorbid medical conditions that are associated with immune dysregulation. To determine whether depression has an association with inflammation independent of medical illness, 1120 adults were screened to identify individuals who had clinically significant depression but not medical conditions associated with systemic inflammation. In total, 66 patients with LLD screened to exclude medical conditions associated with inflammation were studied in detail along with 26 age-matched controls (HC). At baseline, circ

SUBMITTER: Luning Prak ET 

PROVIDER: S-EPMC8948274 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature