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COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients.

ABSTRACT: Vaccination with an mRNA COVID-19 vaccine determines not only a consistent reduction in the risk of SARS-CoV-2 infection but also contributes to disease attenuation in infected people. Of note, hyperinflammation and damage-associated molecular patterns (DAMPs) have been clearly associated with severe illness and poor prognosis in COVID-19 patients. In this report, we revealed a significant reduction in the levels of IL-1ß and DAMPs molecules, as S100A8 and High Mobility Group Protein B1 (HMGB1), in vaccinated patients as compared to non-vaccinated ones. COVID-19 vaccination indeed prevents severe clinical manifestations in patients and limits the release of systemic danger signals in SARS-CoV-2 infected people.

SUBMITTER: Angioni R

PROVIDER: S-EPMC8949226 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients.

Angioni Roberta R Sasset Lolita L Cioccarelli Chiara C Sánchez-Rodríguez Ricardo R Bertoldi Nicole N Putaggio Cristina C CC Viola Antonella A Cattelan Annamaria A Molon Barbara B

Viruses 20220309 3

Vaccination with an mRNA COVID-19 vaccine determines not only a consistent reduction in the risk of SARS-CoV-2 infection but also contributes to disease attenuation in infected people. Of note, hyperinflammation and damage-associated molecular patterns (DAMPs) have been clearly associated with severe illness and poor prognosis in COVID-19 patients. In this report, we revealed a significant reduction in the levels of IL-1ß and DAMPs molecules, as S100A8 and High Mobility Group Protein B1 (HMGB1), ...[more]

PMID: 35336973

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