Calcifediol (25OH Vitamin D3) Deficiency: A Risk Factor from Early to Old Age.

ABSTRACT: Vitamin D deficiency is the main cause of nutritional rickets in children and osteomalacia in adults. There is consensus that nutritional access to vitamin D can be estimated by measuring serum concentrations of 25OHD and vitamin D deficiency can thus be considered as calcifediol deficiency. However, the threshold for vitamin D/calcifediol sufficiency remains a matter of debate. Vitamin D/calcifediol deficiency has been associated with musculoskeletal effects but also multiple adverse extra-skeletal consequences. If these consequences improve or if they can be treated with vitamin D supplementation is still unclear. Observational studies suggest a higher infection risk in people with low calcifediol levels. There is also a consistent association between serum calcifediol and cardiovascular

SUBMITTER: Bouillon R 

PROVIDER: S-EPMC8949915 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature