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Antifouling PVC Catheters by Gamma Radiation-Induced Zwitterionic Polymer Grafting.

ABSTRACT: In medical environments, polymeric surfaces tend to become contaminated, hindering the treatment and recovery from diseases. Biofouling-resistant materials, such as zwitterionic polymers, may mitigate this problem. In this work, the modification of PVC catheters with a binary graft of 4-vinylpyridine (4VP) and sulfobetaine methacrylate (SBMA) by the oxidative pre-irradiation method is proposed to develop pH-responsive catheters with an antifouling capacity. The ionizing radiation allowed us to overcome limitations in the synthesis associated with the monomer characteristics. In addition, the grafted materials showed a considerable increase in their hydrophilic character and antifouling capacity, significantly decreasing the protein adsorption compared to the unmodified catheters. These materials have potential for the development of a combined antimicrobial and antifouling capabilities system to enhance prophylactic activity or even to help treat infections.

SUBMITTER: Duarte-Pena L

PROVIDER: S-EPMC8950535 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Antifouling PVC Catheters by Gamma Radiation-Induced Zwitterionic Polymer Grafting.

Duarte-Peña Lorena L Bucio Emilio E

Polymers 20220316 6

In medical environments, polymeric surfaces tend to become contaminated, hindering the treatment and recovery from diseases. Biofouling-resistant materials, such as zwitterionic polymers, may mitigate this problem. In this work, the modification of PVC catheters with a binary graft of 4-vinylpyridine (4VP) and sulfobetaine methacrylate (SBMA) by the oxidative pre-irradiation method is proposed to develop pH-responsive catheters with an antifouling capacity. The ionizing radiation allowed us to o ...[more]

PMID: 35335516

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