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Galectin-3 in Kidney Diseases: From an Old Protein to a New Therapeutic Target.

ABSTRACT: Galectin-3 (Gal-3) is a 30KDa lectin implicated in multiple pathophysiology pathways including renal damage and fibrosis. Gal-3 binds β-galactoside through its carbohydrate-recognition domain. From intra-cellular to extra-cellular localization, Gal-3 has multiple roles including transduction signal pathway, cell-to-cell adhesion, cell to extracellular matrix adhesion, and immunological chemoattractant protein. Moreover, Gal-3 has also been linked to kidney disease in both preclinical models and clinical studies. Gal-3 inhibition appears to improve renal disease in several pathological conditions, thus justifying the development of multiple drug inhibitors. This review aims to summarize the latest literature regarding Gal-3 in renal pathophysiology, from its role as a biomarker to its potential as a therapeutic agent.

SUBMITTER: Boutin L

PROVIDER: S-EPMC8952808 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Galectin-3 in Kidney Diseases: From an Old Protein to a New Therapeutic Target.

Boutin Louis L Dépret François F Gayat Etienne E Legrand Matthieu M Chadjichristos Christos E CE

International journal of molecular sciences 20220314 6

Galectin-3 (Gal-3) is a 30KDa lectin implicated in multiple pathophysiology pathways including renal damage and fibrosis. Gal-3 binds β-galactoside through its carbohydrate-recognition domain. From intra-cellular to extra-cellular localization, Gal-3 has multiple roles including transduction signal pathway, cell-to-cell adhesion, cell to extracellular matrix adhesion, and immunological chemoattractant protein. Moreover, Gal-3 has also been linked to kidney disease in both preclinical models and ...[more]

PMID: 35328545

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