The role of the farnesoid X receptor in kidney health and disease: a potential therapeutic target in kidney diseases.

ABSTRACT: The prevalence of kidney diseases has been increasing worldwide due to the aging population and has results in an increased socioeconomic burden as well as increased morbidity and mortality. A deep understanding of the mechanisms underlying the physiological regulation of the kidney and the pathogenesis of related diseases can help identify potential therapeutic targets. The farnesoid X receptor (FXR, NR1H4) is a primary nuclear bile acid receptor that transcriptionally regulates bile acid homeostasis as well as glucose and lipid metabolism in multiple tissues. The roles of FXR in tissues other than hepatic and intestinal tissues are poorly understood. In studies over the past decade, FXR has been demonstrated to have a protective effect against kidney diseases through its anti-inflammator

SUBMITTER: Kim DH 

PROVIDER: S-EPMC9981614 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature