Arene Ru(II) Complexes with Difluorinated Ligands Act as Potential Inducers of S-Phase Arrest via the Stabilization of c-myc G-Quadruplex DNA.

ABSTRACT: Here, a series of half-sandwich arene Ru(II) complexes with difluorinated ligands [Ru(η⁶-arene)(L)Cl] (L₁ = 2-(2,3-difluorophenyl)imidazole[4,5f][1,10]-phenanthroline; L₂ = 2-(2,4-difluorophenyl)imidazole[4,5f][1,10]-phenanthroline; arene = benzene, toluene, and p-cymene) were synthesized and characterized. Molecular docking analysis showed that these complexes bind to c-myc G-quadruplex DNA through either groove binding or π-π stacking, and the relative difluorinated site in the main ligand plays a role in regulating the binding mode. The binding behavior of these complexes with c-myc G-quadruplex DNA was evaluated using ultraviolet-visible spectroscopy, fluorescence interc

SUBMITTER: Zeng L 

PROVIDER: S-EPMC8954944 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature