CRISPR-Cas Systems in Gut Microbiome of Children with Autism Spectrum Disorders.

ABSTRACT: The human gut microbiome is associated with various diseases, including autism spectrum disorders (ASD). Variations of the taxonomical composition in the gut microbiome of children with ASD have been observed repeatedly. However, features and parameters of the microbiome CRISPR-Cas systems in ASD have not been investigated yet. Here, we demonstrate such an analysis in order to describe the overall changes in the microbiome CRISPR-Cas systems during ASD as well as to reveal their potential to be used in diagnostics and therapy. For the systems identification, we used a combination of the publicly available tools suited for completed genomes with subsequent filtrations. In the considered data, the microbiomes of children with ASD contained fewer arrays per Gb of assembly than the control gro

SUBMITTER: Zakharevich NV 

PROVIDER: S-EPMC8955288 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature