The impact of hormone receptor on the clinical outcomes of HER2-positive breast cancer: a population-based study.

ABSTRACT:

Background

To investigate the impact of hormone receptor (HR) on the clinicopathological characteristics and prognosis of human epidermal growth factor receptor 2 (HER2)-positive breast cancer.

Methods

Using the Surveillance, Epidemiology, and End Results database, we enrolled patients diagnosed with HER2-positive breast cancer between 2010 and 2016, which were successively assessed for eligibility and categorized into HR + /HER2 + and HR-/HER2 + subgroups. Clinicopathological characteristics were undergone comparative analyses with the baseline distinctions calibrated by propensity score matching, while the survival outcomes were compared using Kaplan-Meier method with log-rank tests.

Results

A total of 46,803 HER2-positive breast cancer patients were identified, of

SUBMITTER: Han Y 

PROVIDER: S-EPMC8956538 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature