Effects of varicocele and microsurgical varicocelectomy on the metabolites in semen.

ABSTRACT: The influence of varicocele and microsurgical varicocelectomy on semen quality remains unclear. Few studies have investigated the relationship between semen metabolism and the abnormalities in reproductive function caused by varicocele, however, there is no study on the changes of semen metabolism after microsurgical varicocelectomy. Here, we used the non-targeted and targeted metabolic analysis to investigate the different metabolites in seminal plasma within normal, varicocele, and varicocelectomy groups. We clearly showed that varicocele significantly affects semen metabolism, and microsurgical varicocelectomy can reverse this metabolic abnormality. Moreover, we characterized the landscape of three dipeptides in the seminal plasma of patients with varicocele that have not been identifie

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8956711 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature