Effect of HIV suppression on the cytokine network in blood and seminal plasma.

ABSTRACT:

Objective

HIV infection disrupts the cytokine network and this disruption is not completely reversed by antiretroviral therapy (ART). Characterization of cytokine changes in blood and genital secretions is important for understanding HIV pathogenesis and the mechanisms of HIV sexual transmission. Here, we characterized the cytokine network in individuals longitudinally sampled before they began ART and after achieving suppression of HIV RNA.

Methods

We measured concentrations of 34 cytokine/chemokines using multiplex bead-based assay in blood and seminal plasma of 19 men with HIV-1 prior to and after viral suppression. We used Partial Least Squares Discriminant Analysis (PLS-DA) to visualize the difference in cytokine pattern between the time points. Any cytokines with VIP s

SUBMITTER: Rawlings SA 

PROVIDER: S-EPMC8957508 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature