Associations of amyloid and neurodegeneration plasma biomarkers with comorbidities.

ABSTRACT:

Introduction

Blood-based biomarkers of amyloid pathology and neurodegeneration are entering clinical use. It is critical to understand what factors affect the levels of these markers.

Methods

Plasma markers (Aβ42, Aβ40, NfL, T-tau, Aβ42/40 ratio) were measured on the Quanterix Simoa HD-1 analyzer for 996 Mayo Clinic Study of Aging (MCSA) participants, aged 51 to 95 years. All other data were collected during in-person MCSA visits or abstracted from the medical record.

Results

Among cognitively unimpaired (CU) participants, all plasma markers correlated with age. Linear regression models revealed multiple relationships. For example, higher Charlson Comorbidity Index and chronic kidney disease were associated with higher levels of all biomarkers. Some relationships diff

SUBMITTER: Syrjanen JA 

PROVIDER: S-EPMC8957642 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature