Ontology highlight
ABSTRACT:
SUBMITTER: Welch CL
PROVIDER: S-EPMC8961593 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Welch Carrie L CL Chung Wendy K WK
Biomolecules 20220207 2
Pulmonary arterial hypertension (PAH) is a rare, progressive vasculopathy with significant cardiopulmonary morbidity and mortality. The underlying pathogenetic mechanisms are heterogeneous and current therapies aim to decrease pulmonary vascular resistance but no curative treatments are available. Causal genetic variants can be identified in ~13% of adults and 43% of children with PAH. Knowledge of genetic diagnoses can inform clinical management of PAH, including multimodal medical treatment, s ...[more]