Pharmacokinetics and pharmacodynamics of repeat dosing of gabapentin in adult horses.

ABSTRACT:

Background

The repeated administration of high doses of gabapentin may provide better analgesia in horses than current clinical protocols.

Hypothesis and objectives

Administration of gabapentin at 40 and 120 mg/kg PO q 12 h for 14 days will not alter serum biochemistry findings or cause adverse effects. Our objectives were to evaluate the effect of gabapentin on serum biochemistry, physical examination, and plasma pharmacokinetics of gabapentin.

Animals

Six healthy adult mares.

Methods

Horses received 40 and 120 mg/kg of gabapentin orally q 12 h for 14 days. Horses were examined and scored for ataxia and sedation daily. Serum biochemistry variables were analyzed before treatment and days 7 and 14 after gabapentin administration. Plasma disposition of gabapentin

SUBMITTER: Gold JR 

PROVIDER: S-EPMC8965223 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature