Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases.

ABSTRACT: Significant progress has been made in understanding the pre-symptomatic phase of amyotrophic lateral sclerosis. While much is still unknown, advances in other neurodegenerative diseases offer valuable insights. Indeed, it is increasingly clear that the well-recognized clinical syndromes of Alzheimer's disease, Parkinson's disease, Huntington's disease, spinal muscular atrophy and frontotemporal dementia are also each preceded by a pre-symptomatic or prodromal period of varying duration, during which the underlying disease process unfolds, with associated compensatory changes and loss of inherent system redundancy. Key insights from these diseases highlight opportunities for discovery in amyotrophic lateral sclerosis. The development of biomarkers reflecting amyloid and tau has led to a shi

SUBMITTER: Benatar M 

PROVIDER: S-EPMC8967095 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature