The association of age with acute toxicities in NRG oncology combined modality lower GI cancer trials.

ABSTRACT:

Purpose

Expected toxicity from chemoradiation (CRT) is an important factor in treatment decisions but is poorly understood in older adults with lower gastrointestinal (GI) malignancies. Our objective was to compare acute adverse events (AAEs) of older and younger adults with lower GI malignancies treated on NRG studies.

Methods

Data from 6 NRG trials, testing combined modality therapy in patients with anal or rectal cancer, were used to test the hypothesis that older age was associated with increased AAEs. AAEs and compliance with protocol-directed therapy were compared between patients aged ≥70 and < 70. Categorical variables were compared across age groups using the chi-square test. The association of age on AAEs was evaluated using a covariate-adjusted logistic regression

SUBMITTER: VanderWalde N 

PROVIDER: S-EPMC8967782 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature