Pre-existing helminth infection impairs the efficacy of adjuvanted influenza vaccination in mice.

ABSTRACT: The world health organization estimates that more than a quarter of the human population is infected with parasitic worms that are called helminths. Many helminths suppress the immune system of their hosts to prolong their survival. This helminth-induced immunosuppression "spills over" to unrelated antigens and can suppress the immune response to vaccination against other pathogens. Indeed, several human studies have reported a negative correlation between helminth infections and responses to vaccinations. Using mice that are infected with the parasitic nematode Litomosoides sigmodontis as a model for chronic human filarial infections, we reported previously that concurrent helminth infection impaired the vaccination-induced protection against the human pathogenic 2009 pandemic H1N1 influe

SUBMITTER: Hartmann W 

PROVIDER: S-EPMC8970517 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature