Molecular Docking as a Potential Approach in Repurposing Drugs Against COVID-19: a Systematic Review and Novel Pharmacophore Models.

ABSTRACT:

Purpose of review

This article provides a review of the recent literature related to the FDA-approved drugs that had been repurposed as potential drug candidates against COVID-19. Moreover, we performed a quality pharmacophore study for frequently studied targets, namely, the main protease, RNA-dependent RNA polymerase, and spike protein.

Recent findings

Ever since the COVID-19 pandemic, the whole spectrum of scientific community is still unable to invent an absolute therapeutic agent for COVID-19. Considering such a fact, drug repurposing strategies seem a truly viable approach to develop novel therapeutic interventions.

Summery

Drug repurposing explores previously approved drugs of known safety and pharmacokinetics profile for possible new effects, reducing the cost

SUBMITTER: Fadlalla M 

PROVIDER: S-EPMC8970976 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature