Maternal iron kinetics and maternal-fetal iron transfer in normal-weight and overweight pregnancy.

ABSTRACT:

Background

Inflammation during pregnancy may aggravate iron deficiency (ID) by increasing serum hepcidin and reducing iron absorption. This could restrict iron transfer to the fetus, increasing risk of infant ID and its adverse effects.

Objectives

We aimed to assess whether iron bioavailability and/or iron transfer to the fetus is impaired in overweight/obese (OW) pregnant women with adiposity-related inflammation, compared with normal-weight (NW) pregnant women.

Methods

In this prospective study, we followed NW (n = 43) and OW (n = 40) pregnant women who were receiving iron supplements from the 14th week of gestation to term and followed their infants to age 6 mo. We administered 57Fe and 58Fe in test meals mid-second and mid-third trimester, and measured tracer kine

SUBMITTER: Stoffel NU 

PROVIDER: S-EPMC8970997 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature