Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC8971594 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Li Zheng Z Yue Muxin M Liu Xuenan X Liu Yunsong Y Lv Longwei L Zhang Ping P Zhou Yongsheng Y
Bioactive materials 20220330
Understanding mechanisms underlying the heterogeneity of multipotent stem cells offers invaluable insights into biogenesis and tissue development. Extracellular matrix (ECM) stiffness has been acknowledged as a crucial factor regulating stem cell fate. However, how cells sense stiffness cues and adapt their metabolism activity is still unknown. Here we report the novel role of mitochondrial phosphoenolpyruvate carboxykinase (PCK2) in enhancing osteogenesis in 3D ECM via glycolysis. We experiment ...[more]