Protective Effects of Familial Longevity Decrease With Age and Become Negligible for Centenarians.

ABSTRACT: It is known that biological relatives of long-lived individuals demonstrate lower mortality and longer life span compared to relatives of shorter-lived individuals, and at least part of this advantage is likely to be genetic. Less information, however, is available about effects of familial longevity on age-specific mortality trajectories. We compared mortality patterns after age 50 years for 10 045 siblings of US centenarians and 12 308 siblings of shorter-lived individuals (died at age 65 years). Similar comparisons were made for sons and daughters of longer-lived parents (both parents lived 80 years and more) and shorter-lived parents (both parents lived less than 80 years) within each group of siblings. Although relatives of longer-lived individuals have lower mortality at younger ages

SUBMITTER: Gavrilova NS 

PROVIDER: S-EPMC8974328 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature