P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke.

ABSTRACT: Stroke is the leading cause of adult disability. Endogenous neural stem/progenitor cells (NSPCs) originating from the subventricular zone (SVZ) contribute to the brain repair process. However, molecular mechanisms underlying CNS disease-induced SVZ NSPC-redirected migration to the lesion area are poorly understood. Here, we show that genetic depletion of the p75 neurotrophin receptor (p75^NTR-/-) in mice reduced SVZ NSPC migration towards the lesion area after cortical injury and that p75^NTR-/- NSPCs failed to migrate upon BDNF stimulation in vitro. Cortical injury rapidly increased p75^NTR abundance in SVZ NSPCs via bone morphogenetic protein (BMP) receptor signaling. SVZ-derived p75^NTR-/- NSPCs revealed an altered cytoskeletal network- and small

SUBMITTER: Deshpande SS 

PROVIDER: S-EPMC8975773 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature