Challenges in defining successful adherence to calorie restriction goals in humans: Results from CALERIE™ 2.

ABSTRACT:

Background

The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE™) phase 2 trial tested the effects of two years of 25% calorie restriction (CR) on aging in humans. CALERIE 2 was one of the first studies to use a graph of predicted weight loss to: 1) provide a proxy of dietary adherence, and 2) promote dietary adherence. Assuming 25% CR, each participant's weight over time was predicted, with upper and lower bounds around predicted weights. Thus, the resulting weight graph included a zone or range of body weights that reflected adherence to 25% CR, and this was named the zone of adherence. Participants were considered adherent if their weight was in this zone. It is unlikely, however, that the entire zone reflects 25% CR.

Objectives

To deter

SUBMITTER: Martin CK 

PROVIDER: S-EPMC8976757 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature