Multistage pH-responsive codelivery liposomal platform for synergistic cancer therapy.

ABSTRACT:

Background

Small interfering RNA (siRNA) is utilized as a potent agent for cancer therapy through regulating the expression of genes associated with tumors. While the widely application of siRNAs in cancer treatment is severely limited by their insufficient biological stability and its poor ability to penetrate cell membranes. Targeted delivery systems hold great promise to selectively deliver loaded drug to tumor site and reduce toxic side effect. However, the elevated tumor interstitial fluid pressure and efficient cytoplasmic release are still two significant obstacles to siRNA delivery. Co-delivery of chemotherapeutic drugs and siRNA represents a potential strategy which may achieve synergistic anticancer effect. Herein, we designed and synthesized a dual pH-responsive peptide

SUBMITTER: Zhao T 

PROVIDER: S-EPMC8976966 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature