Association of Sinusitis and Upper Respiratory Tract Diseases With Incident Rheumatoid Arthritis: A Case-control Study.

ABSTRACT:

Objective

We aimed to determine whether specific respiratory tract diseases are associated with increased rheumatoid arthritis (RA) risk.

Methods

This case-control study within the Mass General Brigham Biobank matched newly diagnosed RA cases to 3 controls on age, sex, and electronic health record history. We identified RA using a validated algorithm and confirmed by medical record review. Respiratory tract disease exposure required 1 inpatient or 2 outpatient codes at least 2 years before the index date of RA clinical diagnosis or matched date. Logistic regression models calculated ORs for RA with 95% CIs, adjusting for confounders. We then stratified by serostatus ("seropositive" was positive rheumatoid factor and/or anticitrullinated protein antibodies) and smoking.

Re

SUBMITTER: Kronzer VL 

PROVIDER: S-EPMC8977280 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature