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Copper-assisted preparation of pyridinyl sulfonate esters from hydroxypyridines and sodium sulfinates.

ABSTRACT: An efficient and powerful copper-assisted method for the effective conversion of a broad range of hydroxypyridines and sodium sulfinates into their corresponding pyridinyl tosylates was developed. Key features of this base- and ligand-free protocol include using the cheap and readily available CuBr₂ as a medium and the use of sodium sulfinates as formal sulfonylation reagents. A variety of functional pyridinyl tosylates could be formed with good yields, which can easily be converted into C-C and C-N bond-containing compounds.

SUBMITTER: Li Q

PROVIDER: S-EPMC8979058 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Copper-assisted preparation of pyridinyl sulfonate esters from hydroxypyridines and sodium sulfinates.

Li Qian Q Zhu Haibo H Liu Yishuai Y Yang Liu L Fan Qiangwen Q Xie Zongbo Z Le Zhang-Gao ZG

RSC advances 20220120 5

An efficient and powerful copper-assisted method for the effective conversion of a broad range of hydroxypyridines and sodium sulfinates into their corresponding pyridinyl tosylates was developed. Key features of this base- and ligand-free protocol include using the cheap and readily available CuBr<sub>2</sub> as a medium and the use of sodium sulfinates as formal sulfonylation reagents. A variety of functional pyridinyl tosylates could be formed with good yields, which can easily be converted i ...[more]

PMID: 35425336

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