Dataset Information
Effect of long-term paired associative stimulation on the modulation of cortical sensorimotor oscillations after spinal cord injury.
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ABSTRACT: Study design
A prospective interventional case series.Objectives
To explore changes in the modulation of cortical sensorimotor oscillations after long-term paired associative stimulation (PAS) in participants with spinal cord injury (SCI).Setting
BioMag Laboratory, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.Methods
Five patients with chronic incomplete SCI received unilateral spinal PAS to upper limb for 16-22 days. Changes in the modulation of sensorimotor oscillations in response to tactile stimulus and active and imaginary hand movements were assessed with magnetoencephalography recorded before and after the intervention.Results
PAS restored the modulation of sensorimotor oscillations in response to active hand movement in four patients, whereas the modulation following tactile stimulation remained unaltered. The observed change was larger in the hemisphere that received PAS and preceded the clinical effect of the intervention.Conclusions
Long-term spinal PAS treatment, which enhances the motor functions of SCI patients, also restores the modulation of cortical sensorimotor oscillations.
SUBMITTER: Vanhanen J
PROVIDER: S-EPMC8980100 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Publications
Effect of long-term paired associative stimulation on the modulation of cortical sensorimotor oscillations after spinal cord injury.
Spinal cord series and cases 20220405 1
<h4>Study design</h4>A prospective interventional case series.<h4>Objectives</h4>To explore changes in the modulation of cortical sensorimotor oscillations after long-term paired associative stimulation (PAS) in participants with spinal cord injury (SCI).<h4>Setting</h4>BioMag Laboratory, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<h4>Methods</h4>Five patients with chronic incomplete SCI received unilateral spinal PAS to upper limb for 16-22 ...[more]