Distinct Immune Response at 1 Year Post-COVID-19 According to Disease Severity.

ABSTRACT:

Background

Despite the fact of ongoing worldwide vaccination programs for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), understanding longevity, breadth, and type of immune response to coronavirus disease-19 (COVID-19) is still important to optimize the vaccination strategy and estimate the risk of reinfection. Therefore, we performed thorough immunological assessments 1 year post-COVID-19 with different severity.

Methods

We analyzed peripheral blood mononuclear cells and plasma samples at 1 year post-COVID-19 in patients who experienced asymptomatic, mild, and severe illness to assess titers of various isotypes of antibodies (Abs) against SARS-CoV-2 antigens, phagocytic capability, and memory B- and T-cell responses.

Findings

A total of 24 patients (7

SUBMITTER: Kang CK 

PROVIDER: S-EPMC8980227 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature