Clinical and imaging analysis to evaluate the response of patients with anti-DPPX encephalitis to immunotherapy.

ABSTRACT:

Background

To report the main spectrum and new clinical and imaging characteristics of dipeptidyl-peptidase-like protein 6 (DPPX) antibody-associated encephalitis, and to evaluate the effect of immunotherapy.

Methods

A retrospective analysis of nine patients with anti-DPPX encephalitis was performed, and all previously reported cases in the literature were reviewed. A cell-based indirect immunofluorescence assay using human embryonic kidney 293 cells transfected with DPPX was used.

Results

Nine patients were identified (median age, 51 years; range, 14-65 years) with prodromal fever, diarrhea, or weight loss, followed by rapid progressive encephalopathy characterized by cognitive disorder. One patient who received methylprednisolone therapy and a trial of tacrolimus sh

SUBMITTER: Xiao J 

PROVIDER: S-EPMC8981927 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature