Roles of C-reactive protein polymorphisms and life event changes on cognitive function in bipolar patients receiving valproate.

ABSTRACT:

Introduction

Patients with bipolar disorder (BD) exhibit an inflamed condition that is associated with metabolic disturbance and cognitive impairment. Whether inflammation, represented by C-reactive protein (CRP), is causally associated with BD and influences treatment outcome has not been established.

Methods

We examined whether CRP is a causal factor for the risk of BD in drug-naïve, depressed BD patients and investigated whether polymorphisms in CRP and life event changes influence cognitive function in BD patients receiving valproate (VPA) treatment.

Results

Our results showed that BD patients had significantly higher CRP levels and worse cognitive function than the controls, while the frequencies of CRP single nucleotide polymorphisms in BD patients

SUBMITTER: Chen PS 

PROVIDER: S-EPMC8984865 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature