Synthesis of chiral sulfinate esters by asymmetric condensation.

ABSTRACT: Achiral sulfur functional groups, such as sulfonamide, sulfone, thiol and thioether, are common in drugs and natural products. By contrast, chiral sulfur functional groups are often neglected as pharmacophores^1-3, although sulfoximine, with its unique physicochemical and pharmacokinetic properties^4,5, has been recently incorporated into several clinical candidates. Thus, other sulfur stereogenic centres, such as sulfinate ester, sulfinamide, sulfonimidate ester and sulfonimidamide, have started to attract attention. The diversity and complexity of these sulfur stereogenic centres have the potential to expand the chemical space for drug discovery^6-10. However, the installation of these structures enantioselectively into drug molecules is highly challenging.

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8985065 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature