L-type calcium channel blocker use and proteinuria among children with chronic kidney diseases.

ABSTRACT:

Background

Hypertension is common among children with chronic kidney disease (CKD), and dihydropyridine calcium channel blockers (dhCCBs) are frequently used as treatment. The impact of dhCCBs on proteinuria in children with CKD is unclear.

Methods

Data from 722 participants in the Chronic Kidney Disease in Children (CKiD) longitudinal cohort with a median age of 12 years were used to assess the association between dhCCBs and log transformed urine protein/creatinine levels as well as blood pressure control measured at annual visits. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blocker (ARB) use was evaluated as an effect measure modifier.

Results

Individuals using dhCCBs had 18.8% higher urine protein/creatinine levels compared to those with

SUBMITTER: Richardson KL 

PROVIDER: S-EPMC8985842 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature