Ontology highlight
ABSTRACT:
SUBMITTER: Fessler E
PROVIDER: S-EPMC8986780 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Fessler Evelyn E Krumwiede Luisa L Jae Lucas T LT
Nature communications 20220406 1
Protein homeostatic control of mitochondria is key to age-related diseases and organismal decline. However, it is unknown how the diverse types of stress experienced by mitochondria can be integrated and appropriately responded to in human cells. Here we identify perturbations in the ancient conserved processes of mitochondrial protein import and processing as sources of DELE1 activation: DELE1 is continuously sorted across both mitochondrial membranes into the matrix and detects different types ...[more]