Oligomers of hepatitis A virus (HAV) capsid protein VP1 generated in a heterologous expression system.

ABSTRACT:

Background

The quasi-enveloped picornavirus, Hepatitis A Virus (HAV), causes acute hepatitis in humans and infects approximately 1.5 million individuals a year, which does not include the asymptomatically infected population. Several severe outbreaks in developing nations in recent years have highlighted the reduction in HAV endemicity, which increases the risk of infections in the vulnerable population. The current HAV vaccines are based on growing wildtype or attenuated virus in cell culture, which raises the cost of production. For generation of cheaper, subunit vaccines or strategies for antibody-based diagnostics, production of viral structural proteins in recombinant form in easily accessible expression systems is a priority.

Results

We attempted several strategies for

SUBMITTER: Nain A 

PROVIDER: S-EPMC8991588 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature