Characteristics of the gut microbiota in pregnant women with fetal growth restriction.

ABSTRACT:

Background

Fetal growth restriction (FGR) in utero leads to failure of fetus to reach the genetically normal growth potential. Currently available means of treating FGR are limited. And it remains unknown how pregnant women who give birth to FGR fetus differ in gut microbiota composition from normal pregnant women.

Methods

In this case-control study, fecal samples were obtained from maternal rectum in the operation room by an obstetrician under strict aseptic conditions. We compared gut microbiota of 14 pregnant women with FGR and 18 normal controls by performing 16S rDNA amplicon sequencing.

Results

We identified significant differences in β-diversity between the FGR and control groups (P < 0.05). At genus level, Bacteroides, Faecalibacterium and Lachnospira were hig

SUBMITTER: Tu X 

PROVIDER: S-EPMC8991653 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature