Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic.
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ABSTRACT: Background
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) seroprevalence studies largely focus on adults, but little is known about spread in children. We determined SARS-CoV-2 seroprevalence in children and adolescents from Arkansas over the first year of the coronavirus disease of 2019 (COVID-19) pandemic.Methods
We tested remnant serum samples from children ages 1-18 years who visited Arkansas hospitals or clinics for non-COVID-19-related reasons from April 2020 through April 2021 for SARS-CoV-2 antibodies. We used univariable and multivariable regression models to determine the association between seropositivity and participant characteristics.Results
Among 2357 participants, seroprevalence rose from 7.9% in April/May 2020 (95% CI, 4.9-10.9) to 25.0% in April 2021 (95% CI, 21.5-28.5). Hispanic and black children had a higher association with antibody positivity than non-Hispanic and white children, respectively, in multiple sampling periods.Conclusions
By spring 2021, most children in Arkansas were not infected with SARS-CoV-2. With the emergence of SARS-CoV-2 variants, recognition of long-term effects of COVID-19, and the lack of an authorized pediatric SARS-CoV-2 vaccine at the time, these results highlight the importance of including children in SARS-CoV-2 public health, clinical care, and research strategies.
SUBMITTER: Boehme KW
PROVIDER: S-EPMC8992271 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Publications
Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic.
Boehme Karl W KW Kennedy Joshua L JL Snowden Jessica J Owens Shana M SM Kouassi Marianne M Mann Ryan L RL Paredes Amairani A Putt Claire C James Laura L Jin Jing J Du Ruofei R Kirkpatrick Catherine C Modi Zeel Z Caid Katherine K Young Sean S Zohoori Namvar N Kothari Atul A Boyanton Bobby L BL Craig Forrest J J
Journal of the Pediatric Infectious Diseases Society 20220601 6
<h4>Background</h4>Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) seroprevalence studies largely focus on adults, but little is known about spread in children. We determined SARS-CoV-2 seroprevalence in children and adolescents from Arkansas over the first year of the coronavirus disease of 2019 (COVID-19) pandemic.<h4>Methods</h4>We tested remnant serum samples from children ages 1-18 years who visited Arkansas hospitals or clinics for non-COVID-19-related reasons from April 2020 ...[more]
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2022-04-29 | E-MTAB-11240 | biostudies-arrayexpress
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