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SARS-CoV-2 and human retroelements: a case for molecular mimicry?

ABSTRACT:

Background

The factors driving the late phase of COVID-19 are still poorly understood. However, autoimmunity is an evolving theme in COVID-19's pathogenesis. Additionally, deregulation of human retroelements (RE) is found in many viral infections, and has also been reported in COVID-19.

Results

Unexpectedly, coronaviruses (CoV) - including SARS-CoV-2 - harbour many RE-identical sequences (up to 35 base pairs), and some of these sequences are part of SARS-CoV-2 epitopes associated to COVID-19 severity. Furthermore, RE are expressed in healthy controls and human cells and become deregulated after SARS-CoV-2 infection, showing mainly changes in long interspersed nuclear element (LINE1) expression, but also in endogenous retroviruses.

Conclusion

CoV and human RE share coding sequences, which are targeted by antibodies in COVID-19 and thus could induce an autoimmune loop by molecular mimicry.

SUBMITTER: Koch BF

PROVIDER: S-EPMC8992427 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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SARS-CoV-2 and human retroelements: a case for molecular mimicry?

Koch Benjamin Florian BF

BMC genomic data 20220408 1

<h4>Background</h4>The factors driving the late phase of COVID-19 are still poorly understood. However, autoimmunity is an evolving theme in COVID-19's pathogenesis. Additionally, deregulation of human retroelements (RE) is found in many viral infections, and has also been reported in COVID-19.<h4>Results</h4>Unexpectedly, coronaviruses (CoV) - including SARS-CoV-2 - harbour many RE-identical sequences (up to 35 base pairs), and some of these sequences are part of SARS-CoV-2 epitopes associated ...[more]

PMID: 35395708

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