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Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage.

ABSTRACT: Global genomic surveillance of SARS-CoV-2 has identified variants associated with increased transmissibility, neutralization resistance and disease severity. Here we report the emergence of the PANGO lineage C.1.2, detected at low prevalence in South Africa and eleven other countries. The initial C.1.2 detection is associated with a high substitution rate, and includes changes within the spike protein that have been associated with increased transmissibility or reduced neutralization sensitivity in SARS-CoV-2 variants of concern or variants of interest. Like Beta and Delta, C.1.2 shows significantly reduced neutralization sensitivity to plasma from vaccinees and individuals infected with the ancestral D614G virus. In contrast, convalescent donors infected with either Beta or Delta show high plasma neutralization against C.1.2. These functional data suggest that vaccine efficacy against C.1.2 will be equivalent to Beta and Delta, and that prior infection with either Beta or Delta will likely offer protection against C.1.2.

SUBMITTER: Scheepers C

PROVIDER: S-EPMC8993834 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage.

Scheepers Cathrine C Everatt Josie J Amoako Daniel G DG Tegally Houriiyah H Wibmer Constantinos Kurt CK Mnguni Anele A Ismail Arshad A Mahlangu Boitshoko B Lambson Bronwen E BE Martin Darren P DP Wilkinson Eduan E San James Emmanuel JE Giandhari Jennifer J Manamela Nelia N Ntuli Noxolo N Kgagudi Prudence P Cele Sandile S Richardson Simone I SI Pillay Sureshnee S Mohale Thabo T Ramphal Upasana U Naidoo Yeshnee Y Khumalo Zamantungwa T ZT Kwatra Gaurav G Gray Glenda G Bekker Linda-Gail LG Madhi Shabir A SA Baillie Vicky V Van Voorhis Wesley C WC Treurnicht Florette K FK Venter Marietjie M Mlisana Koleka K Wolter Nicole N Sigal Alex A Williamson Carolyn C Hsiao Nei-Yuan NY Msomi Nokukhanya N Maponga Tongai T Preiser Wolfgang W Makatini Zinhle Z Lessells Richard R Moore Penny L PL de Oliveira Tulio T von Gottberg Anne A Bhiman Jinal N JN

Nature communications 20220408 1

Global genomic surveillance of SARS-CoV-2 has identified variants associated with increased transmissibility, neutralization resistance and disease severity. Here we report the emergence of the PANGO lineage C.1.2, detected at low prevalence in South Africa and eleven other countries. The initial C.1.2 detection is associated with a high substitution rate, and includes changes within the spike protein that have been associated with increased transmissibility or reduced neutralization sensitivity ...[more]

PMID: 35396511

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Dataset Information

Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage.

Publications

Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage.

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