Dataset Information

Epidemiology and outcomes of gastrointestinal mucosal melanomas: a national database analysis.

ABSTRACT:

Aim

Gastrointestinal malignant melanoma is a rare mucosal melanoma (MM). Other MM include the respiratory and the genitourinary tract. All mucosal melanomas have a poor prognosis when compared to cutaneous melanomas. Ano-rectal melanomas are by far the most common and most studied gastrointestinal MM. Large-scale clinical data is lacking due to the rarity of the disease. We aim to analyze epidemiology and survival of the Gastrointestinal (G.I.) MM over 45 years using a national database.

Methods

The Surveillance, Epidemiology and End Results (SEER) database was queried to identify patients with biopsy-proven G.I. Melanomas. We selected tumor site, intervention, and survival information for oncology codes as per the international classification of diseases. Survival analysis was performed using the SPSS v 27 ® IBM software.

Results

Of the 1105 biopsy-proven confirmed cases of primary G.I. melanoma's, 191 (17.3%) received chemotherapy (C.T.), 202 (18.3%) received radiotherapy (R.T.), 63 (5.7%) received both C.T and R.T., while 684 (61.9%) of the population received surgery alone or combined with C.T. and/or R.T. Statistically significant improvement in survival was noted in all treatment strategies that utilized surgery and also when site-specific MM cohorts underwent a surgical approach with or without C.T and/or R.T.

Conclusion

This is the most extensive study reporting epidemiological and survival data of treatment strategy outcomes of primary G.I. mucosal melanoma elucidating best overall survival with a management strategy involving surgical intervention.

SUBMITTER: Shah NJ

PROVIDER: S-EPMC8994909 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Epidemiology and outcomes of gastrointestinal mucosal melanomas: a national database analysis.

Shah Niraj James NJ Aloysius Mark M MM Bhanat Eldrin E Gupta Shweta S Aswath Ganesh G John Savio S Tang Shou-Jiang SJ Goyal Hemant H

BMC gastroenterology 20220409 1

<h4>Aim</h4>Gastrointestinal malignant melanoma is a rare mucosal melanoma (MM). Other MM include the respiratory and the genitourinary tract. All mucosal melanomas have a poor prognosis when compared to cutaneous melanomas. Ano-rectal melanomas are by far the most common and most studied gastrointestinal MM. Large-scale clinical data is lacking due to the rarity of the disease. We aim to analyze epidemiology and survival of the Gastrointestinal (G.I.) MM over 45 years using a national database. ...[more]

PMID: 35397529

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Dataset Information

Epidemiology and outcomes of gastrointestinal mucosal melanomas: a national database analysis.

Aim

Methods

Results

Conclusion

Publications

Epidemiology and outcomes of gastrointestinal mucosal melanomas: a national database analysis.

Similar Datasets

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