Neuromotor control associates with muscle weakness observed with McArdle sign of multiple sclerosis.

ABSTRACT:

Objective

Multiple Sclerosis (MS) is often accompanied by myelopathy, which may be associated with progressive worsening. A specific finding of MS-associated myelopathy is McArdle sign, wherein neck flexion is associated with prominent increased limb weakness relative to that detected with neck extension. In this study, we characterized neuromotor control properties of finger extensors in association with the McArdle sign.

Methods

A custom-built device was utilized to monitor torque production of the wrist extensors with simultaneous recording of surface electromyography of the extensor digitorum. The electromyography was decomposed and analyzed via both linear and nominal regressions.

Results

Linear regressions demonstrated a strong difference between groups for MS f

SUBMITTER: Schilaty ND 

PROVIDER: S-EPMC8994990 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature