Ontology highlight
ABSTRACT:
SUBMITTER: Ma Y
PROVIDER: S-EPMC8995209 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Ma Yitong Y Budde Mark W MW Mayalu Michaëlle N MN Zhu Junqin J Lu Andrew C AC Murray Richard M RM Elowitz Michael B MB
Cell 20220301 6
In multicellular organisms, cells actively sense and control their own population density. Synthetic mammalian quorum-sensing circuits could provide insight into principles of population control and extend cell therapies. However, a key challenge is reducing their inherent sensitivity to "cheater" mutations that evade control. Here, we repurposed the plant hormone auxin to enable orthogonal mammalian cell-cell communication and quorum sensing. We designed a paradoxical population control circuit ...[more]