Propofol Alone versus Propofol in Combination with Midazolam for Sedative Endoscopy in Patients with Paradoxical Reactions to Midazolam.

ABSTRACT:

Background/aims

The efficacy of propofol in gastrointestinal endoscopy for patients with midazolam-induced paradoxical reactions remains unclarified. This study aimed to compare the efficacy and safety of propofol-based sedation in patients who previously experienced paradoxical reactions.

Methods

This was a prospective, single-blinded, randomized controlled pilot study. Participants with a history of paradoxical reactions to midazolam during a previous esophagogastroduodenoscopy were recruited and randomly assigned to group I (propofol monosedation) or group II (combination of propofol and midazolam). The primary endpoint was the occurrence of a paradoxical reaction.

Results

A total of 30 participants (mean age, 54.7±12.6 years; male, 19/30) were randomly assigned to

SUBMITTER: Nam JH 

PROVIDER: S-EPMC8995981 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature