MGluR₅ and GABA_A receptor-specific parametric PET atlas construction-PET/MR data processing pipeline, validation, and application.

ABSTRACT: The glutamate and γ-aminobutyric acid neuroreceptor subtypes mGluR₅ and GABA_A are hypothesized to be involved in the development of a variety of psychiatric diseases. However, detailed information relating to their in vivo distribution is generally unavailable. Maps of such distributions could potentially aid clinical studies by providing a reference for the normal distribution of neuroreceptors and may also be useful as covariates in advanced functional magnetic resonance imaging (MR) studies. In this study, we propose a comprehensive processing pipeline for the construction of standard space, in vivo distributions of non-displaceable binding potential (BP_ND ), and total distribution volume (V_T ) based on simultaneously acquired bolus-infusion p

SUBMITTER: Kaulen N 

PROVIDER: S-EPMC8996359 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature