Minimally Invasive Preclinical Monitoring of the Peritoneal Cavity Tumor Microenvironment.

ABSTRACT: Intraperitoneal (i.p.) experimental models in mice can recapitulate the process of i.p. dissemination in abdominal cancers and may help uncover critical information about future successful clinical treatments. i.p. cellular composition is studied in preclinical models addressing a wide spectrum of other pathophysiological states such as liver cirrhosis, infectious disease, autoimmunity, and aging. The peritoneal cavity is a multifaceted microenvironment that contains various immune cell populations, including T, B, NK, and various myeloid cells, such as macrophages. Analysis of the peritoneal cavity is often obtained by euthanizing mice and performing terminal peritoneal lavage. This procedure inhibits continuous monitoring of the peritoneal cavity in a single mouse and necessitates the us

SUBMITTER: Dunn ZS 

PROVIDER: S-EPMC8997523 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature