Simvastatin Prevents Liver Microthrombosis and Sepsis Induced Coagulopathy in a Rat Model of Endotoxemia.

ABSTRACT:

Background

Endotoxemia causes endothelial dysfunction and microthrombosis, which are pathogenic mechanisms of coagulopathy and organ failure during sepsis. Simvastatin has potential anti-thrombotic effects on liver endothelial cells. We investigated the hemostatic changes induced by lipopolysaccharide (LPS) and explored the protective effects of simvastatin against liver vascular microthrombosis.

Methods and results

We compared male Wistar rats exposed to LPS (5 mg/kg one i.p. dose) or saline in two experimental protocols-placebo (vehicle) and simvastatin (25 mg/kg die, orally, for 3 days before LPS). Morphological studies were performed by light- and electron-microscopy analyses to show intravascular fibrin deposition, vascular endothelial structure and liver damage. Periph

SUBMITTER: La Mura V 

PROVIDER: S-EPMC8997834 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature