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In Vivo and In Vitro Cartilage Differentiation from Embryonic Epicardial Progenitor Cells.

ABSTRACT: The presence of cartilage tissue in the embryonic and adult hearts of different vertebrate species is a well-recorded fact. However, while the embryonic neural crest has been historically considered as the main source of cardiac cartilage, recently reported results on the wide connective potential of epicardial lineage cells suggest they could also differentiate into chondrocytes. In this work, we describe the formation of cardiac cartilage clusters from proepicardial cells, both in vivo and in vitro. Our findings report, for the first time, cartilage formation from epicardial progenitor cells, and strongly support the concept of proepicardial cells as multipotent connective progenitors. These results are relevant to our understanding of cardiac cell complexity and the responses of cardiac connective tissues to pathologic stimuli.

SUBMITTER: Palmquist-Gomes P

PROVIDER: S-EPMC8999123 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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In Vivo and In Vitro Cartilage Differentiation from Embryonic Epicardial Progenitor Cells.

Palmquist-Gomes Paul P Marín-Sedeño Ernesto E Ruiz-Villalba Adrián A Rico-Llanos Gustavo Adolfo GA Pérez-Pomares José María JM Guadix Juan Antonio JA

International journal of molecular sciences 20220325 7

The presence of cartilage tissue in the embryonic and adult hearts of different vertebrate species is a well-recorded fact. However, while the embryonic neural crest has been historically considered as the main source of cardiac cartilage, recently reported results on the wide connective potential of epicardial lineage cells suggest they could also differentiate into chondrocytes. In this work, we describe the formation of cardiac cartilage clusters from proepicardial cells, both in vivo and in ...[more]

PMID: 35408974

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