External chest-wall compression in prolonged COVID-19 ARDS with low-compliance: a physiological study.

ABSTRACT:

Background

External chest-wall compression (ECC) is sometimes used in ARDS patients despite lack of evidence. It is currently unknown whether this practice has any clinical benefit in patients with COVID-19 ARDS (C-ARDS) characterized by a respiratory system compliance (C_rs) < 35 mL/cmH₂O.

Objectives

To test if an ECC with a 5 L-bag in low-compliance C-ARDS can lead to a reduction in driving pressure (DP) and improve gas exchange, and to understand the underlying mechanisms.

Methods

Eleven patients with low-compliance C-ARDS were enrolled and underwent 4 steps: baseline, ECC for 60 min, ECC discontinuation and PEEP reduction. Respiratory mechanics, gas exchange, hemodynamics and electrical impedance tomography were recorded. Four pigs with acute

SUBMITTER: Bastia L 

PROVIDER: S-EPMC9003155 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature