Dataset Information

The association between rs1260326 with the risk of NAFLD and the mediation effect of triglyceride on NAFLD in the elderly Chinese Han population.

ABSTRACT:

Background

Accumulated studies have pointed out the striking association between variants in or near APOC3, GCKR, PNPLA3, and nonalcoholic fatty liver disease (NAFLD) at various ages from multiple ethnic groups. This association remained unclear in the Chinese Han elderly population, and whether this relationship correlated to any clinical parameters was also unclear.

Objectives

This study aims to decipher the complex relevance between gene polymorphisms, clinical parameters, and NAFLD by association study and mediation analysis.

Methods

Eight SNPs (rs2854116, rs2854117, rs780093, rs780094, rs1260362, rs738409, rs2294918, and rs2281135) within APOC3, GCKR, and PNPLA3 were genotyped using the MassARRAY® platform in a large Chinese Han sample comprising of 733 elderly NAFLD patients and 824 age- and ethnic-matched controls. Association and mediation analysis were employed by R.

Results

The genotypic frequencies of rs1260326 and rs780094 were significantly different between NAFLD and control (rs1260326: P=0.004, P_corr=0.020, OR [95%CI]= 0.69 [0.54-0.89]; rs780094: P=0.005, P_corr=0.025, OR [95%CI]= 0.70 [0.55-0.90]). Particularly, an increased triglyceride level was observed in carriers of rs1260326 T allele (1.94±1.19 mmol/L) compared with non-carriers (1.73±1.05 mmol/L).no significant results were observed in rs780094. Notably, triglyceride levels had considerably indirect impacts on association between NAFLD and rs1260326 (β =0.01, 95% CI: 0.01-0.02), indicating that 12.7% of the association of NAFLD with rs1260326 was mediated by triglyceride levels.

Conclusions

Our results identified a prominent relationship between GCKR rs1260326 and NAFLD, and highlighted the mediated effect of triglyceride levels on the that association in the Chinese Han elderly.

SUBMITTER: Yuan F

PROVIDER: S-EPMC9004570 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Publications

The association between rs1260326 with the risk of NAFLD and the mediation effect of triglyceride on NAFLD in the elderly Chinese Han population.

Yuan Fan F Gu Zhan Z Bi Yan Y Yuan Ruixue R Niu Weibo W Ren Decheng D Zhang Lei L He Guang G Liu Bao-Cheng BC

Aging 20220325 6

<h4>Background</h4>Accumulated studies have pointed out the striking association between variants in or near <i>APOC3</i>, <i>GCKR</i>, <i>PNPLA3</i>, and nonalcoholic fatty liver disease (NAFLD) at various ages from multiple ethnic groups. This association remained unclear in the Chinese Han elderly population, and whether this relationship correlated to any clinical parameters was also unclear.<h4>Objectives</h4>This study aims to decipher the complex relevance between gene polymorphisms, clin ...[more]

PMID: 35333773

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Dataset Information

The association between rs1260326 with the risk of NAFLD and the mediation effect of triglyceride on NAFLD in the elderly Chinese Han population.

Background

Objectives

Methods

Results

Conclusions

Publications

The association between rs1260326 with the risk of NAFLD and the mediation effect of triglyceride on NAFLD in the elderly Chinese Han population.

Similar Datasets

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