MiR-203, fine-tunning neuroinflammation by juggling different components of NF-κB signaling.

ABSTRACT:

Background

miR-203 was first indicated in maintaining skin homeostasis and innate immunity. Aberrant expression of miR-203 was found associated with pathological progressions of immune disorders, cancers, as well as neurodegenerations. Recently, increasing data on miR-203 in regulating neuroinflammation and neuronal apoptosis has raised extensive concern about the biological function of this microRNA.

Methods

Mouse model with ectopic miR-203 expression in the hippocampus was constructed by stereotactic injection of lentiviral expression vector of pre-miR-203. Association of miR-203 and mRNA of Akirin2, as well as the competition for miR-203 targeting between Akirin2 3'UTR and another recently characterized miR-203 target, 14-3-3θ, was verified using Dual-Luciferase Reporter

SUBMITTER: Li S 

PROVIDER: S-EPMC9006621 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature